A June 2014 article in the New England Journal of Medicine (NEJM), written by researchers from the National Institute on Drug Abuse and the National In­stitutes of Health, points out that marijuana is not the harmless drug that many imagine. Rather, it is as­sociated with "substantial adverse effects, some of which have been determined with a high level of con­fidence." 

These negative outcomes in­clude the risk of addiction, symp­toms of chronic bronchitis, an ele­vated incidence of fatal and non-fatal motor vehicle accidents, and diminished lifetime achievement and school performance in cases of long term use, especially beginning in adolescence. We can add that the decision to use a drug recreationally for the purposes of dissociating ourselves from reality through in­duced euphoria raises significant moral concerns, and, like all unethi­cal human choices, can be expected to correlate with significant adverse ramifications.

Part of the unethical character of drug abuse flows from the fact that we are treating something good, namely our personal, con­scious experience as if it were an evil to be avoided. Recreational drug users seek to escape or other­wise suppress their lived conscious experience, and instead pursue chemically-altered states of mind, or drug-induced pseudo-experi­ences. Any time we act in such a way that we treat some­thing ob­jectively good as if it were an evil by acting directly against it, we act in a disordered and immoral manner. 

The decision to pursue ine­briation and drunkenness, simi­larly, is a choice directed against the good of our human conscious experience that raises serious moral concerns. The responsible enjoyment of alcohol, meanwhile, presupposes that a moderate use of the fruit of the vine can aid us in the pursuit of certain aspects of friendship and interaction by stimulating conversation with others, and by diminishing the hesitations that people may have when they interact with each other. The moderate use of alco­hol also appears to offer positive physiological effects on health. The notion of the “responsible enjoyment of marijuana and other mind-altering drugs,” meanwhile, is a dubious concept, given that the more powerful and varied neurological effects of these sub­stances readily take us across a line into alternate states of mind, detachment from reality, “getting stoned,” etc.

Whenever we look at alcohol, marijuana, or other more powerful drugs, additional moral concerns arise due to the risk of addiction, which threatens authentic freedom and con­stitutes a serious form of human bondage. Alcohol, of course, poses a significant risk of addiction for some people, and the responsible use of alcohol may become nearly impossi­ble for them, necessitating complete abstinence to maintain their freedom. Marijuana, despite some contentious debates about the matter, similarly has a significant addictive potential, as noted in the NEJM article:

“Approximately 9 percent of those who experiment with marijuana will become addicted… The number goes up to about 1 in 6 among those who start using marijuana as teenag­ers and to 25 to 50 percent among those who smoke mari­juana daily. According to the 2012 National Survey on Drug Use and Health, an estimated 2.7 million people 12 years of age and older met the DSM-IV criteria for dependence on marijuana, and 5.1 million peo­ple met the criteria for depend­ence on any illicit drug (8.6 mil­lion met the criteria for depend­ence on alcohol)… Indeed, early and regular marijuana use pre­dicts an increased risk of mari­juana addiction, which in turn predicts an increased risk of the use of other illicit drugs.” 

The NEJM article also notes that adults who smoke marijuana regularly during adolescence have decreased neural connectivity (ab­normal brain development and fewer fibers) in specific brain regions. Al­though some experts have disputed a cause-effect relationship for this phe­nomenon, studies of brain develop­ment in animals strongly suggest a causal effect. The authors surmise that the effects of marijuana on brain devel­opment may help to explain the asso­ciation between frequent mari­juana use among adolescents and sig­nifi­cant declines in IQ, as well as poor academic performance and an in­creased risk of dropping out of school. These deleterious effects speak to us of the fundamentally un­ethical character of inhaling, injecting or otherwise ingesting harmful chemical substances into our bodies.

The litany of marijuana’s ad­verse health effects raises major doubts about the wisdom of pro­moting its legalization for recreational purposes. The authors note that the health effects of a drug (whether legal or illegal) are related to its “availabil­ity and social acceptability.” They conclude, “In this respect, legal drugs (alcohol and tobacco) offer a sober­ing perspective, accounting for the greatest burden of disease associated with drugs not because they are more dangerous than illegal drugs but be­cause their legal status allows for more widespread exposure,” leading to more abuse and more harmful ef­fects. It's critical for us to acknowl­edge these negative effects rather than seeking, like drug addicts, to dissociate ourselves from this reality.

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